John P Newnham Selected Research

Betamethasone (Celestone)

1/2022	Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in combination with betamethasone acetate.
1/2018	The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy.
1/2018	Extremely preterm fetal sheep lung responses to antenatal steroids and inflammation.
12/2013	Modulation of lipopolysaccharide-induced chorioamnionitis in fetal sheep by maternal betamethasone.
1/2013	Effects of intra-amniotic lipopolysaccharide and maternal betamethasone on brain inflammation in fetal sheep.
2/2012	Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs.
1/2009	Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep.
7/2008	Repeated betamethasone treatment of pregnant sheep programs persistent reductions in circulating IGF-I and IGF-binding proteins in progeny.
1/2008	Maternal betamethasone and chorioamnionitis induce different collagenases during lung maturation in fetal sheep.
7/2007	Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs.

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John P Newnham Research Topics

Disease

41	Inflammation (Inflammations) 01/2021 - 03/2002
31	Chorioamnionitis 01/2021 - 07/2002
17	Premature Birth (Birth, Premature) 01/2021 - 01/2002
17	Pneumonia (Pneumonitis) 01/2018 - 03/2002
14	Infections 11/2020 - 10/2010
10	Body Weight (Weight, Body) 01/2019 - 01/2002
8	Fetal Weight 01/2021 - 11/2003
6	Birth Weight (Birth Weights) 01/2022 - 01/2002
5	Premature Obstetric Labor (Premature Labor) 01/2022 - 09/2002
5	Insulin Resistance 10/2017 - 10/2005
4	Bronchopulmonary Dysplasia 03/2013 - 03/2002
4	Fetal Growth Retardation (Intrauterine Growth Retardation) 08/2007 - 01/2002
3	Ureaplasma Infections (Ureaplasma Infection) 01/2017 - 09/2010
3	Lung Injury 12/2007 - 09/2002
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 12/2020 - 05/2009
2	Brain Injuries (Brain Injury) 11/2020 - 01/2019
2	Gestational Diabetes (Gestational Diabetes Mellitus) 10/2017 - 09/2014
2	Rupture 01/2016 - 08/2014
2	Pregnancy Complications 01/2016 - 09/2006
2	Pain (Aches) 01/2013 - 06/2006
1	Anemia 04/2022
1	Hemorrhage 04/2022
1	Methemoglobinemia 04/2022
1	Cholestasis 01/2021
1	Intrahepatic Cholestasis of Pregnancy 01/2021
1	Pruritus (Itching) 01/2021
1	Hypotension (Low Blood Pressure) 11/2020
1	Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced) 01/2020
1	Hypertension (High Blood Pressure) 01/2020
1	Amblyopia (Lazy Eye) 01/2020
1	Exotropia (Exophoria) 01/2020
1	Anisometropia 01/2020
1	Esotropia (Esophoria) 01/2020
1	Hypospadias 01/2018
1	Disease Progression 01/2018
1	Varicocele 01/2018
1	Cryptorchidism (Undescended Testes) 01/2018
1	Bacteremia 10/2017
1	Sepsis (Septicemia) 01/2017

Drug/Important Bio-Agent (IBA)

24	LipopolysaccharidesIBA 01/2021 - 08/2005
19	Betamethasone (Celestone)FDA Link 01/2022 - 01/2002
16	EndotoxinsIBA 03/2011 - 03/2002
13	CytokinesIBA 10/2017 - 11/2005
11	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 01/2002
10	GlucocorticoidsIBA 12/2013 - 09/2002
9	Messenger RNA (mRNA)IBA 01/2017 - 04/2005
9	Interleukin-1 (Interleukin 1)IBA 01/2016 - 03/2002
7	Proteins (Proteins, Gene)FDA Link 09/2014 - 04/2005
5	SteroidsIBA 01/2022 - 12/2016
5	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 10/2010
5	Interleukin-8 (Interleukin 8)IBA 09/2014 - 11/2003
5	Surface-Active Agents (Surfactants)IBA 05/2009 - 03/2002
4	InterleukinsIBA 01/2021 - 05/2006
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017 - 07/2003
3	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 04/2009
3	Fluconazole (Zonal)FDA LinkGeneric 02/2016 - 06/2015
3	MacrolidesIBA 01/2016 - 06/2011
3	solithromycinIBA 01/2016 - 01/2014
3	Interleukin-6 (Interleukin 6)IBA 09/2014 - 04/2009
3	Erythromycin (Erycette)FDA LinkGeneric 08/2014 - 10/2010
2	betamethasone sodium phosphate FDA LinkGeneric 01/2022 - 01/2018
2	Bacterial DNAIBA 01/2021 - 01/2021
2	ChemokinesIBA 01/2017 - 06/2014
2	Azithromycin (Zithromax)FDA LinkGeneric 09/2014 - 06/2011
2	Progesterone FDA LinkGeneric 01/2014 - 09/2002
2	AntigensIBA 01/2012 - 09/2010
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2011 - 04/2009
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 05/2009 - 11/2005
2	Budesonide (Pulmicort)FDA LinkGeneric 07/2007 - 11/2003
2	ProstaglandinsIBA 09/2006 - 07/2002
2	Interleukin-1alpha (Interleukin 1 alpha)IBA 09/2006 - 03/2002
2	Saline SolutionIBA 11/2003 - 10/2002
1	Nitroglycerin (Dynamite)FDA LinkGeneric 04/2022
1	APTIBA 04/2022
1	Acetates (Acetic Acid Esters)FDA Link 01/2022
1	betamethasone acetate FDA LinkGeneric 01/2022
1	Rifampin (Rifampicin)FDA LinkGeneric 01/2021
1	TabletsIBA 01/2021
1	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 01/2021
1	101.10 peptideIBA 01/2021
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2021
1	dexamethasone 21-phosphate FDA LinkGeneric 11/2020
1	Illicit Drugs (Recreational Drugs)IBA 01/2020
1	phthalic acid (phthalate)IBA 01/2018
1	Testosterone (Sustanon)FDA Link 01/2018
1	Diethylhexyl Phthalate (DEHP)IBA 01/2018
1	betamethasone acetate phosphate FDA LinkGeneric 01/2018
1	AdipokinesIBA 10/2017
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2017
1	2- ((aminocarbonyl)amino)- 5- (4- fluorophenyl)- 3- thiophenecarboxamideIBA 01/2017
1	Complement System Proteins (Complement)IBA 01/2017
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017

Therapy/Procedure

9	Therapeutics 01/2022 - 01/2008
5	Injections 07/2008 - 01/2002
2	Euthanasia (Mercy Killing) 04/2022 - 01/2019
2	Intramuscular Injections 12/2003 - 12/2003
2	Aftercare (After-Treatment) 04/2003 - 10/2002
1	Blood Transfusion (Blood Transfusions) 04/2022
1	Catheters 01/2021
1	Prenatal Care (Care, Prenatal) 12/2020